
GR 82334
CAS No. 129623-01-4
GR 82334 ( —— )
产品货号. M30679 CAS No. 129623-01-4
Tachykinin NK1 receptor antagonist.
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
100MG | 获取报价 | 有现货 |
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200MG | 获取报价 | 有现货 |
![]() ![]() |
500MG | 获取报价 | 有现货 |
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生物学信息
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产品名称GR 82334
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述Tachykinin NK1 receptor antagonist.
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产品描述Tachykinin NK1 receptor antagonist.
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体外实验——
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体内实验GR 82334 (intrathecal administration; 0.1 nmol-1 nmol) excites rats unnary bladder motihty at 1 nmol but not at 0.1 nmol, and the reflex chemonociceptive is reduced by the topical application of capsaicin (4 μg/50 ul).GR 82334 (10 nM-1 μM; injected between vertebrae L4 and L5) has no effect at 10 nM in neither species, increases heat-induced foot withdrawal latency in mice at doses >100 nM, but no such increase in naked mole-rats, where doses >100 nM evoke a tendency for decreased latency. Animal Model:3-6 month-old, male C57BL/6 mice and 6-18 month-old naked mole-rats Dosage:10 nM, 100 nM, and 1 μM Administration:Lntrathecal injection between vertebrae L4 and L5?Result:Increased heat-induced foot withdrawal latency in mice.
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同义词——
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通路Others
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靶点Other Targets
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受体——
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研究领域——
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适应症——
化学信息
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CAS Number129623-01-4
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分子量1386.57
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分子式C69H91N15O16
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纯度>98% (HPLC)
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溶解度water:1 mg/mL
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SMILESCC(C)C[C@H](N1CC[C@@]2(CCCN2C(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H]2CCC(=O)N2)C1=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(N)=O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Guo et al (1995) Pharmacological characterisation of GR82334, a tachykinin NK1 receptor antagonist, in the isolated spinal cord of the neonatal rat. Eur.J.Pharmacol. 281 49 PMID:
产品手册




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